Cell-Based Assay Services

BioreclamationIVT offers primary cell-based assay services for drug development which constitute the most accurate disease modeling and surpass cell lines, 3D organ culture and animal models. The assays cover many conditions, e.g., oncological, cardiovascular, metabolic, autoimmune, degenerative, genetic, aging-related etc.

From contract laboratory services to project management and consulting, your project will be tailored to answer your specific concerns.

Discuss Your Project With Us
  • Cell Toxicity
  • Drug Candidate Efficacy Testing
  • Mitochondrial Dysfunction
    • ATP, MTT
  • Oxidative Stress
    • ROS, RNS, Super Oxide
  • IC50/EC50 Determination
  • Pluripotency Marker Profiling
  • DNA Damage
    • PARP Assay
Class Compound Readout
AMPK Agonist AICAR
Metformin
Annexin-V detection; ATP concentrations
Annexin-V detection
AMPK Inhibitor Compound C Annexin-V detection
Chromatin Remodeler BRG1
BRM
OCT4, GCAP expression levels
OCT4, GCAP expression levels
FGF Agonist bFGF OCT4, REX1, hTERT expression levels
GSK3 Inhibitor CHIR99021 XIST RNA levels
Histone Modifier 5-aza-dC
Trichostatin A
OCT4, GCAP expression levels
OCT4, GCAP expression levels
LIF/STAT3 Agonist LIF
IL-6
XIST RNA levels
XIST RNA levels
MAPK Inhibitor PD0325901 XIST RNA levels
STAT3 Inhibitor NSC 74859 XIST RNA levels
Tyrosine Kinase Inhibitor CH5424802 ATP concentrations

Available Biomarker Assays

Acylcarnitines Free Fatty Acids Polyamine Oxidase
Adiponectin FSH Polymyxin B
AGE-CML Ghrelin RAGE
Alpha-Antichymotrypsin Glucose RANKL
alpha/beta-Estradiol Glutamate RBP-4
AMPK-alpha (total and phospho) HbA1c Retinoic Acid Receptor-alpha
Apolipoprotein A1 hCG ROS
Apolipoprotein B HDL S100
Apolipoprotein B-48 Hepcidin sCD14
Apolipoprotein C-III hGH Serotonin
Apolipoprotein E Histamine SHBG
ATP Homocysteine Sphingomyelin
Bile Acids I-FABP Sphingosine
Brain Natriuretic Peptide ICAM-1 sVEGFR1/Flt1
C-peptide IFN-gamma T3 (total)
C-telopeptides IGF-1 T4 (free)
Ceramides IGFBP-3 T4 (total)
Cholesterol IL-10 Tacrolimus
Corticosteroid Binding Globulin mTOR Taxol
Cortisol MTT/XTT TBARS
Cortisol MTT/XTT TBARS
Cotinine N-telopeptide TBG
DHEA-Sulphate Neopterin TCA-intermediates
Diacylglycerides Neuropeptide Y TGF-beta
DNA Methylation NGAL Theobromine
Dopamine NSE Theophylline
Doxorubicin OPG TNF-alpha
e-Selectin Osteocalcin Topotecan
Endocannabinoids p53 Transferrin
Endothelin-1 PARP TRAP-5b
Epinephrin Pentosidine Triglycerides
Fatty Acyl CoA Phenylalanine Enrichment Tryptophan
Fibrinogen PINP TSH
Folic Acid Polyamine Oxidase Uncarboxylated Osteocalcin
FRAP Polymyxin B Vasopressin

Note: This list is not all-inclusive. Please contact us if your study requires other assay targets.

We work with a variety of primary cells. Our expertise in cell culture allows us to produce data from even the most challenging cell types.

  • Adipocytes
  • Astrocytes
  • Bone Marrow Stem Cells
  • Cord Blood Stem Cells
  • Endothelial Cells
  • Enterocytes
  • Epithelial Cells
  • Fibroblasts
  • Hepatocytes
  • Lymphocytes (T cells, B cells)
  • Monocytes
  • Osteoblasts
  • PBMCs
  • Renal Cells
  • Skeletal Muscle Cells
  • Skeletal Myocytes
  • Smooth Muscle Cells
  • Splenocytes

 

 

 

Along with our biospecimens, we also provide a wide range of testing services from standard clinical assays.

Clinical Lab Testing

  • Albumin
  • CA 125
  • CA 19-9
  • CBC
  • pH
  • HCG value
  • PSA value
  • Rheumatoid factor
  • Total protein
  • Lipid profile (cholesterol and triglycerides)
  • Infectious agents: CMV/HIV/HBV/HCV