InVitroCYP™ M-class microsomes

InvitroCYP-M-Class-MicrosomesHuman liver microsomes are subcellular fractions that contain drug-metabolizing enzymes including CYP enzymes, flavin monooxygenases, and UDP glucuronyl transferases. InVitroCYP M-class microsomes are designed to exhibit moderate CYP activity, ideal for clearance and metabolite identification studies. BioreclamationIVT' extensive characterization and tissue profiling process guarantees that each lot of InVitroCYP M-class microsomes will provide consistent and reproducible results for your metabolism and clearance studies.

  CYP Substrate Metabolites Units
AMO CYP2C8: Amodiaquine Decentralization Amodiaquine N-Desethylamodiaquine pmole/min/mg
BUP CYP2B6: Bupropion hydroxylation Bupropion Hydroxybupropion pmole/min/mg
COUM CYP2A6: Coumarin 7-hydroxylation Coumarin 7-HCG, 7-HCS, 7-HC pmole/min/mg
CZX CYP2E1: Chlorzoxazone 6-hydroxylation Chlorzoxazone 6-Hydroxychlorzoxazone pmole/min/mg
DEX CYP2D6: Dextromethorphan O-demethylation Dextromethorphan Dextrorphan pmole/min/mg
ECOD Multiple CYPs: 7-Ethoxycoumarin O-deethylation 7-Ethoxycoumarin 7-HCG, 7-HCS, 7-HC pmole/min/mg
MEPH CYP2C19: S-Mephenytoin 4'-hydroxylation S-Mephenytoin 4'-Hydroxymephenytoin pmole/min/mg
MID CYP3A4: Midazolam 1-hydroxylation Midazolam 1-Hydroxymidazolam pmole/min/mg
PHEN CYP1A2: Phenacetin O-deethylation Phenacetin Acetominophen pmole/min/mg
TEST CYP3A4: Testosterone 6ß-hydroxylation Testosterone 6β-Hydroxytestosterone pmole/min/mg
UGT UGT: 7-Hydroxycoumarin glucuronidation 7-Hydroxycoumarin 7-Hydroxycoumarin glucuronide pmole/min/mg
TOLB CYP2C9: Tolbutamide methyl-hydroxylation Tolbutamide 4'-Methylhydroxytolbutamide pmole/min/mg